Inhibition of Connexin 43 reverses ox-LDL-mediated inhibition of autophagy in VSMC by inhibiting the PI3K/Akt/mTOR signaling pathway

BACKGROUND: Oxidized low-density lipoproteins (ox-LDL) may induce foam cell formation from the vascular smooth muscle cell (VSMC) by inhibiting VSMC autophagy. This process accelerates the formation of atherosclerosis (AS). Connexin 43 (Cx43), which is the most widely distributed connexin in VSMC is...

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Detalles Bibliográficos
Autores principales: Qin, Xuqing, He, Wenjun, Yang, Rui, Liu, Luqian, Zhang, Yingying, Li, Li, Si, Junqiang, Li, Xinzhi, Ma, Ketao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934045/
https://www.ncbi.nlm.nih.gov/pubmed/35313522
http://dx.doi.org/10.7717/peerj.12969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934045/
https://www.ncbi.nlm.nih.gov/pubmed/35313522
http://dx.doi.org/10.7717/peerj.12969

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