APOE4 confers transcriptomic and functional alterations to primary mouse microglia

Common genetic variants in more than forty loci modulate risk for Alzheimer’s disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of AD. A major genetic risk factor for AD...

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Detalles Bibliográficos
Autores principales: Machlovi, Saima I., Neuner, Sarah M., Hemmer, Brittany M., Khan, Riana, Liu, Yiyuan, Huang, Min, Zhu, Jeffrey D., Castellano, Joseph M., Cai, Dongming, Marcora, Edoardo, Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934202/
https://www.ncbi.nlm.nih.gov/pubmed/35031484
http://dx.doi.org/10.1016/j.nbd.2022.105615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934202/
https://www.ncbi.nlm.nih.gov/pubmed/35031484
http://dx.doi.org/10.1016/j.nbd.2022.105615

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