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APOE4 confers transcriptomic and functional alterations to primary mouse microglia
Common genetic variants in more than forty loci modulate risk for Alzheimer’s disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of AD. A major genetic risk factor for AD...
Autores principales: | Machlovi, Saima I., Neuner, Sarah M., Hemmer, Brittany M., Khan, Riana, Liu, Yiyuan, Huang, Min, Zhu, Jeffrey D., Castellano, Joseph M., Cai, Dongming, Marcora, Edoardo, Goate, Alison M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934202/ https://www.ncbi.nlm.nih.gov/pubmed/35031484 http://dx.doi.org/10.1016/j.nbd.2022.105615 |
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