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Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice

The homeodomain transcription factor SIX3 is a known regulator of eye, nose, and forebrain development, and has recently been implicated in female reproduction. Germline heterozygosity of SIX3 is sufficient to cause subfertility, but the cell populations that mediate this role are unknown. The neuro...

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Detalles Bibliográficos
Autores principales: Lavalle, Shanna N., Chou, Teresa, Hernandez, Jacqueline, Naing, Nay Chi P., He, Michelle Y., Tonsfeldt, Karen J., Mellon, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934285/
https://www.ncbi.nlm.nih.gov/pubmed/35121076
http://dx.doi.org/10.1016/j.mce.2022.111577