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Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models
BACKGROUND: Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathology is unknown. Siah1-interacting protein (SIP) acts as an a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934500/ https://www.ncbi.nlm.nih.gov/pubmed/35305696 http://dx.doi.org/10.1186/s13578-022-00755-0 |