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Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

BACKGROUND: Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathology is unknown. Siah1-interacting protein (SIP) acts as an a...

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Detalles Bibliográficos
Autores principales:	Latoszek, Ewelina, Wiweger, Małgorzata, Ludwiczak, Jan, Dunin-Horkawicz, Stanisław, Kuznicki, Jacek, Czeredys, Magdalena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934500/ https://www.ncbi.nlm.nih.gov/pubmed/35305696 http://dx.doi.org/10.1186/s13578-022-00755-0

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