Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice

In clinical practice, pregabalin is orally administered for neuropathic pain, but causes severe central nervous system side effects, such as dizziness, which results in dose limitation or discontinuation. To reduce the central side effects of pregabalin, we developed four pregabalin preparations for...

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Detalles Bibliográficos
Autores principales: Nagao, Michiru, Tajima, Masataka, Sugiyama, Erika, Shinouchi, Ryosuke, Shibata, Keita, Yoshikawa, Masayuki, Yamamoto, Takushi, Sato, Vilasinee Hirunpanich, Nobe, Koji, Sato, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934619/
https://www.ncbi.nlm.nih.gov/pubmed/35306752
http://dx.doi.org/10.1002/prp2.919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934619/
https://www.ncbi.nlm.nih.gov/pubmed/35306752
http://dx.doi.org/10.1002/prp2.919

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