Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Two families of DNA glycosylases (YtkR2/AlkD, AlkZ/YcaQ) have been found to remove bulky and crosslinking DNA adducts produced by bacterial natural products. Whether DNA glycosylases eliminate other types of damage formed by structurally diverse antibiotics is unknown. Here, we identify four DNA gly...

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Detalles Bibliográficos
Autores principales: Chen, Xiaorong, Bradley, Noah P, Lu, Wei, Wahl, Katherine L, Zhang, Mei, Yuan, Hua, Hou, Xian-Feng, Eichman, Brandt F, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934636/
https://www.ncbi.nlm.nih.gov/pubmed/35191495
http://dx.doi.org/10.1093/nar/gkac085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934636/
https://www.ncbi.nlm.nih.gov/pubmed/35191495
http://dx.doi.org/10.1093/nar/gkac085

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