CRISPRpas: programmable regulation of alternative polyadenylation by dCas9

Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity. Here, by using a catalytically dead...

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Detalles Bibliográficos
Autores principales: Shin, Jihae, Ding, Qingbao, Wang, Luyang, Cui, Yange, Baljinnyam, Erdene, Guvenek, Aysegul, Tian, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934653/
https://www.ncbi.nlm.nih.gov/pubmed/34244761
http://dx.doi.org/10.1093/nar/gkab519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934653/
https://www.ncbi.nlm.nih.gov/pubmed/34244761
http://dx.doi.org/10.1093/nar/gkab519

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