Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops

Some proteins, like the lac repressor (LacI), mediate long-range loops that alter DNA topology and create torsional barriers. During transcription, RNA polymerase generates supercoiling that may facilitate passage through such barriers. We monitored E. coli RNA polymerase progress along templates in...

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Detalles Bibliográficos
Autores principales: Xu, Wenxuan, Yan, Yan, Artsimovitch, Irina, Dunlap, David, Finzi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934669/
https://www.ncbi.nlm.nih.gov/pubmed/35188572
http://dx.doi.org/10.1093/nar/gkac093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934669/
https://www.ncbi.nlm.nih.gov/pubmed/35188572
http://dx.doi.org/10.1093/nar/gkac093

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