A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity

Treatment response to clopidogrel is associated with CYP2C19 activity through the formation of the active H4 metabolite. The aims of this study were to develop a physiologically based pharmacokinetic (PBPK) model of clopidogrel and its metabolites for populations of European ancestry, to predict the...

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Detalles Bibliográficos
Autores principales: Duong, Janna K., Nand, Romina A., Patel, Aarti, Della Pasqua, Oscar, Gross, Annette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934724/
https://www.ncbi.nlm.nih.gov/pubmed/35307978
http://dx.doi.org/10.1002/prp2.946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934724/
https://www.ncbi.nlm.nih.gov/pubmed/35307978
http://dx.doi.org/10.1002/prp2.946

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