Cargando…

Multi-patient dose synthesis of [(18)F]Flumazenil via a copper-mediated (18)F-fluorination

BACKGROUND: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABA(A)Rs). Positron Emission Tomography (PET) imaging of the GABAARs with [(11)C]FMZ has been used to evidenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gendron, Thibault, Destro, Gianluca, Straathof, Natan J. W., Sap, Jeroen B. I., Guibbal, Florian, Vriamont, Charles, Caygill, Claire, Atack, John R., Watkins, Andrew J., Marshall, Christopher, Hueting, Rebekka, Warnier, Corentin, Gouverneur, Véronique, Tredwell, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934836/ https://www.ncbi.nlm.nih.gov/pubmed/35306596 http://dx.doi.org/10.1186/s41181-022-00158-z

Ejemplares similares

Synthesis of (18)F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [(18)F]fluoride
por: Sap, Jeroen B. I., et al.
Publicado: (2019)

Correction: Pacelli et al. Fully Automated, High-Dose Radiosynthesis of [18F]PARPi. Pharmaceuticals 2022, 15, 865
por: Pacelli, Anna, et al.
Publicado: (2023)

Asymmetric (18)F-fluorination for applications in positron emission tomography
por: Buckingham, Faye, et al.
Publicado: (2016)

[(18)F]AZD2461, an Insight on Difference in PARP Binding Profiles for DNA Damage Response PET Imaging
por: Guibbal, Florian, et al.
Publicado: (2020)

Closing the gap between (19)F and (18)F chemistry
por: Ajenjo, Javier, et al.
Publicado: (2021)

(18)F-fluorodeoxyglucose and (18)F-flumazenil positron emission tomography in patients with refractory epilepsy
por: Hodolic, Marina, et al.
Publicado: (2016)

Correction to: Closing the gap between (19)F and (18)F chemistry
por: Ajenjo, Javier, et al.
Publicado: (2022)

Imaging PARP with [(18)F]rucaparib in pancreatic cancer models
por: Chan, Chung Ying, et al.
Publicado: (2022)

Correlation between molar activity, injection mass and uptake of the PARP targeting radiotracer [(18)F]olaparib in mouse models of glioma
por: Chan, Chung Ying, et al.
Publicado: (2022)

Hypoxia Imaging Using PET and SPECT: The Effects of Anesthetic and Carrier Gas on [(64)Cu]-ATSM, [(99m)Tc]-HL91 and [(18)F]-FMISO Tumor Hypoxia Accumulation
por: Kersemans, Veerle, et al.
Publicado: (2011)

Fluorine-18 Labeled Fluorofuranylnorprogesterone ([(18)F]FFNP) and Dihydrotestosterone ([(18)F]FDHT) Prepared by “Fluorination on Sep-Pak” Method
por: Basuli, Falguni, et al.
Publicado: (2019)

PET Imaging of PARP Expression Using (18)F-Olaparib
por: Wilson, Thomas C., et al.
Publicado: (2019)

Effects of common anesthetic agents on [(18)F]flumazenil binding to the GABA(A) receptor
por: Palner, Mikael, et al.
Publicado: (2016)

Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic (18)F-Fluorination
por: Gendron, Thibault, et al.
Publicado: (2018)

Synthesis of [(18)F]Arenes via the Copper-Mediated [(18)F]Fluorination of Boronic Acids
por: Mossine, Andrew V., et al.
Publicado: (2015)

Single and double stereoselective fluorination of (E)-allylsilanes
por: Sawicki, Marcin, et al.
Publicado: (2007)

Fully automated (18)F-fluorination of N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) for indirect labelling of nanobodies
por: Nagachinta, Surasa, et al.
Publicado: (2022)

(18)F-Trifluoromethanesulfinate Enables Direct C–H (18)F-Trifluoromethylation of Native Aromatic Residues in Peptides
por: Kee, Choon Wee, et al.
Publicado: (2020)

(18)F-Fluorination: Challenge and Opportunity for Organic Chemists
por: Halder, Riya, et al.
Publicado: (2021)

Effective Preparation of [(18)F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor
por: Haskali, Mohammad B., et al.
Publicado: (2022)

Automated Synthesis of [(18)F]Flumazenil Application in GABA(A) Receptor Neuroimaging Availability for Rat Model of Anxiety
por: Farn, Shiou-Shiow, et al.
Publicado: (2023)

A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes
por: Yuan, Gengyang, et al.
Publicado: (2020)

Fluorinated carbohydrates for (18)F-positron emission tomography (PET)
por: Campbell, Emma, et al.
Publicado: (2023)

Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
por: Ichiishi, Naoko, et al.
Publicado: (2014)

Moving Metal-Mediated (18)F-Fluorination from Concept to Clinic
por: Sanford, Melanie S., et al.
Publicado: (2016)

Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
por: Lahdenpohja, Salla, et al.
Publicado: (2020)

Radiosynthesis of 5-[(18)F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[(18)F]Fluorine Exchange Reaction
por: Zhang, Xiang, et al.
Publicado: (2021)

Development and application of decatungstate catalyzed C–H (18)F- and (19)F-fluorination, fluoroalkylation and beyond
por: Yuan, Zheliang, et al.
Publicado: (2023)

(18)F-Fluorine-18-l-dihydroxyphenylalanine ((18)F-DOPA) positive isolated peritoneal carcinomatosis from a MENII-related medullary thyroid carcinoma. About an atypical metastatic site and utility of (18)F-FDOPA
por: Aziz, Anne-Laure, et al.
Publicado: (2015)

[(18)F]-Fluorinated Carboplatin and [(111)In]-Liposome for Image-Guided Drug Delivery
por: Lamichhane, Narottam, et al.
Publicado: (2017)

Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling
por: Szpera, Robert, et al.
Publicado: (2020)

(18)F-meta-fluorobenzylguanidine ((18)F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models
por: Turnock, Stephen, et al.
Publicado: (2020)

PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
por: Ishibashi, Kenji, et al.
Publicado: (2017)

Enhanced Aqueous Suzuki–Miyaura Coupling Allows Site-Specific Polypeptide (18)F-Labeling
por: Gao, Zhanghua, et al.
Publicado: (2013)

Cu-Mediated C–H (18)F-Fluorination of Electron-Rich (Hetero)arenes
por: McCammant, Matthew S., et al.
Publicado: (2017)

Toward Novel [(18)F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils
por: Uzuegbunam, Bright C., et al.
Publicado: (2022)

Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis
por: Yankam Njiwa, J., et al.
Publicado: (2014)

Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18
por: Sander, Kerstin, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of an (18)Fluorine-Labeled COX Inhibitor—[(18)F]Fluorooctyl Fenbufen Amide—For Imaging of Brain Tumors
por: Huang, Ying-Cheng, et al.
Publicado: (2016)

Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [(18)F] FDG Yield Potent Sensors of Living Bacteria In Vivo
por: Sorlin, Alexandre M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tlofoo1ft7v96b75a5ohfuna2k