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Pairs of Mutually Compensatory Frameshifting Mutations Contribute to Protein Evolution

Insertions and deletions of lengths not divisible by 3 in protein-coding sequences cause frameshifts that usually induce premature stop codons and may carry a high fitness cost. However, this cost can be partially offset by a second compensatory indel restoring the reading frame. The role of such pa...

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Detalles Bibliográficos
Autores principales: Biba, Dmitry, Klink, Galya, Bazykin, Georgii A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935012/
https://www.ncbi.nlm.nih.gov/pubmed/35137193
http://dx.doi.org/10.1093/molbev/msac031