Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling

Background: Intervertebral disc degeneration (IDD), the main cause of low back pain, is closely related to the inflammatory microenvironment in the nucleus pulposus (NP). Tumor necrosis factor-α (TNF-α) plays an important role in inflammation-related metabolic disturbance of NP cells. Melatonin has...

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Detalles Bibliográficos
Autores principales: Qiu, Xianjian, Liang, Tongzhou, Wu, Zizhao, Zhu, Yuanxin, Gao, Wenjie, Gao, Bo, Qiu, Jincheng, Wang, Xudong, Chen, Taiqiu, Deng, Zhihuai, Li, Pengfei, Chen, Yanbo, Zhou, Hang, Peng, Yan, Xu, Caixia, Su, Peiqiang, Liang, Anjing, Huang, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935230/
https://www.ncbi.nlm.nih.gov/pubmed/35342351
http://dx.doi.org/10.7150/ijbs.65973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935230/
https://www.ncbi.nlm.nih.gov/pubmed/35342351
http://dx.doi.org/10.7150/ijbs.65973

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