Development of high-affinity nanobodies specific for Na(V)1.4 and Na(V)1.5 voltage-gated sodium channel isoforms

Voltage-gated sodium channels, Na(V)s, are responsible for the rapid rise of action potentials in excitable tissues. Na(V) channel mutations have been implicated in several human genetic diseases, such as hypokalemic periodic paralysis, myotonia, and long-QT and Brugada syndromes. Here, we generated...

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Detalles Bibliográficos
Autores principales: Srinivasan, Lakshmi, Alzogaray, Vanina, Selvakumar, Dakshnamurthy, Nathan, Sara, Yoder, Jesse B., Wright, Katharine M., Klinke, Sebastián, Nwafor, Justin N., Labanda, María S., Goldbaum, Fernando A., Schön, Arne, Freire, Ernesto, Tomaselli, Gordon F., Amzel, L. Mario, Ben-Johny, Manu, Gabelli, Sandra B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935509/
https://www.ncbi.nlm.nih.gov/pubmed/35202650
http://dx.doi.org/10.1016/j.jbc.2022.101763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935509/
https://www.ncbi.nlm.nih.gov/pubmed/35202650
http://dx.doi.org/10.1016/j.jbc.2022.101763

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