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Differential parathyroid and kidney Ca(2+)-sensing receptor activation in autosomal dominant hypocalcemia 1

BACKGROUND: Parathyroid Ca(2+)-sensing receptor (CaSR) activation inhibits parathyroid hormone (PTH) release, while activation of renal CaSRs attenuates Ca(2+) transport and increases expression of the pore-blocking claudin-14. Patients with autosomal dominant hypocalcemia 1 (ADH1), due to activatin...

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Detalles Bibliográficos
Autores principales: van Megen, Wouter H., Tan, Rebecca Siu Ga, Alexander, R. Todd, Dimke, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935519/
https://www.ncbi.nlm.nih.gov/pubmed/35313217
http://dx.doi.org/10.1016/j.ebiom.2022.103947