Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?

Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and ApoE4) and heterozygous carriers of the ε4 allele of the gene encoding ApoE (APOE) have a fourfold greater risk of developing Alzh...

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Detalles Bibliográficos
Autores principales: Vecchio, Filomena Lo, Bisceglia, Paola, Imbimbo, Bruno Pietro, Lozupone, Madia, Latino, Raffaela Rita, Resta, Emanuela, Leone, Maurizio, Solfrizzi, Vincenzo, Greco, Antonio, Daniele, Antonio, Watling, Mark, Panza, Francesco, Seripa, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935560/
https://www.ncbi.nlm.nih.gov/pubmed/35321401
http://dx.doi.org/10.1177/20406223221081605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935560/
https://www.ncbi.nlm.nih.gov/pubmed/35321401
http://dx.doi.org/10.1177/20406223221081605

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