A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines

BACKGROUND: Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity of aromatic amines using commercially available, quantitative structure–activi...

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Detalles Bibliográficos
Autores principales: Furukawa, Ayaka, Ono, Satoshi, Yamada, Katsuya, Torimoto, Nao, Asayama, Mahoko, Muto, Shigeharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935809/
https://www.ncbi.nlm.nih.gov/pubmed/35313995
http://dx.doi.org/10.1186/s41021-022-00238-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935809/
https://www.ncbi.nlm.nih.gov/pubmed/35313995
http://dx.doi.org/10.1186/s41021-022-00238-1

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