Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target this state as an approach to inhibit RAS function. Here, we desc...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Imran, Koide, Akiko, Zuberi, Mariyam, Ketavarapu, Gayatri, Denbaum, Eric, Teng, Kai Wen, Rhett, J. Matthew, Spencer-Smith, Russell, Hobbs, G. Aaron, Camp, Ernest Ramsay, Koide, Shohei, O’Bryan, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936000/
https://www.ncbi.nlm.nih.gov/pubmed/35139380
http://dx.doi.org/10.1016/j.celrep.2022.110322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936000/
https://www.ncbi.nlm.nih.gov/pubmed/35139380
http://dx.doi.org/10.1016/j.celrep.2022.110322

Ejemplares similares