Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed. Overlooked in these approaches is the loss of one co...

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Detalles Bibliográficos
Autores principales: Pulianmackal, Ajai J., Kanakousaki, Kiriaki, Flegel, Kerry, Grushko, Olga G., Gourley, Ella, Rozich, Emily, Buttitta, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938402/
https://www.ncbi.nlm.nih.gov/pubmed/35107131
http://dx.doi.org/10.1242/dmm.049234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938402/
https://www.ncbi.nlm.nih.gov/pubmed/35107131
http://dx.doi.org/10.1242/dmm.049234

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