Cargando…

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease

Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) is involved in the extensive fibrosis of renal tissue by facilitating the partial epithelial-mesenchymal transition (EMT), increasing the synthesis of extracellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Wei, Zhou, Xingcheng, Xu, Tingting, Mao, Yanwen, Zhang, Xiaohuan, Liu, Huiming, Liang, Luqun, Liu, Lingling, Liu, Lirong, Xiao, Ying, Zhang, Fan, Li, Shuang, Shi, Mingjun, Zhou, Yuxia, Tang, Lei, Wang, Yuanyuan, Guo, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938433/ https://www.ncbi.nlm.nih.gov/pubmed/35314669 http://dx.doi.org/10.1038/s41419-022-04529-x

Ejemplares similares

SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy
por: Liu, Lirong, et al.
Publicado: (2017)

BMP-7 enhances SnoN mRNA expression in renal tubular epithelial cells under high-glucose conditions
por: Wang, Yuanyuan, et al.
Publicado: (2017)

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
por: Walldén, Karin, et al.
Publicado: (2017)

Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway
por: Liu, Lirong, et al.
Publicado: (2016)

TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes
por: Maeda, Shingo, et al.
Publicado: (2012)

SnoN facilitates ALK1–Smad1/5 signaling during embryonic angiogenesis
por: Zhu, Qingwei, et al.
Publicado: (2013)

SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis
por: Chi, Cheng, et al.
Publicado: (2023)

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
por: Tecalco-Cruz, Angeles C., et al.
Publicado: (2018)

Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy
por: Xu, Zhuojia, et al.
Publicado: (2017)

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
por: Javelaud, Delphine, et al.
Publicado: (2011)

The role of CDX2 in renal tubular lesions during diabetic kidney disease
por: Liu, Huiming, et al.
Publicado: (2021)

Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats
por: Chi, Cheng, et al.
Publicado: (2018)

SnoN Facilitates Axonal Regeneration after Spinal Cord Injury
por: Do, Jiun L., et al.
Publicado: (2013)

Jiangtang Tongmai Prescription Reduced Diabetic Lung Injury Through SnoN and TGF-β1/Smads Signaling Pathway
por: Ding, Nian, et al.
Publicado: (2022)

TGF-β Repressors SnoN and Ski Are Implicated in Human Colorectal Carcinogenesis
por: Bravou, Vasiliki, et al.
Publicado: (2009)

The influence of SnoN gene silencing by siRNA on the cell proliferation and apoptosis of human pancreatic cancer cells
por: Liu, Chengli, et al.
Publicado: (2015)

Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression
por: Xiang, Jiayi, et al.
Publicado: (2022)

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
por: Chia, June A, et al.
Publicado: (2006)

The Proteasome Inhibitor, MG132, Attenuates Diabetic Nephropathy by Inhibiting SnoN Degradation In Vivo and In Vitro
por: Huang, Wei, et al.
Publicado: (2014)

Transforming growth factor β(1 )inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
por: Ehnert, Sabrina, et al.
Publicado: (2012)

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface
por: Nyman, Tomas, et al.
Publicado: (2010)

Expression Profiles of SnoN in Normal and Cancerous Human Tissues Support Its Tumor Suppressor Role in Human Cancer
por: Jahchan, Nadine S., et al.
Publicado: (2013)

Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids
por: Chanda, Ayan, et al.
Publicado: (2023)

Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation
por: Xu, Hao, et al.
Publicado: (2021)

Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells
por: Kodigepalli, Karthik M, et al.
Publicado: (2013)

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine
por: Xiao, Yawen, et al.
Publicado: (2022)

miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells
por: SONG, QILING, et al.
Publicado: (2015)

Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-β Signaling Pathway
por: Laigle, Victor, et al.
Publicado: (2021)

Expression of BMP-4 and Smad1 in patients with Hirschsprung disease and its clinical significance
por: Zhang, Jianjun, et al.
Publicado: (2019)

Smad1 stabilization and delocalization in response to the blockade of BMP activity
por: Li, Lili, et al.
Publicado: (2013)

Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling
por: Wu, Jian, et al.
Publicado: (2021)

Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway
por: Shan, Yangyang, et al.
Publicado: (2018)

Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling
por: Li, Wenqing, et al.
Publicado: (2017)

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
por: Zou, Ming-Li, et al.
Publicado: (2021)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

Msk is required for nuclear import of TGF-β/BMP-activated Smads
por: Xu, Lan, et al.
Publicado: (2007)

BMP‐Smad Signaling Regulates Postnatal Crown Dentinogenesis in Mouse Molar
por: Omi, Maiko, et al.
Publicado: (2019)

BMP-7 suppresses excessive scar formation by activating the BMP-7/Smad1/5/8 signaling pathway
por: Guo, Jingdong, et al.
Publicado: (2017)

Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease
por: Wang, Dan, et al.
Publicado: (2023)

Does Smad6 methylation control BMP signaling in cancer?
por: Xu, Jian, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vagkfuohbfar9c195v6jl1jq3l