Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation

Gene regulatory elements play a key role in orchestrating gene expression during cellular differentiation, but what determines their function over time remains largely unknown. Here, we perform perturbation-based massively parallel reporter assays at seven early time points of neural differentiation...

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Detalles Bibliográficos
Autores principales: Kreimer, Anat, Ashuach, Tal, Inoue, Fumitaka, Khodaverdian, Alex, Deng, Chengyu, Yosef, Nir, Ahituv, Nadav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938438/
https://www.ncbi.nlm.nih.gov/pubmed/35315433
http://dx.doi.org/10.1038/s41467-022-28659-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938438/
https://www.ncbi.nlm.nih.gov/pubmed/35315433
http://dx.doi.org/10.1038/s41467-022-28659-0

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