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Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation
Gene regulatory elements play a key role in orchestrating gene expression during cellular differentiation, but what determines their function over time remains largely unknown. Here, we perform perturbation-based massively parallel reporter assays at seven early time points of neural differentiation...
Autores principales: | Kreimer, Anat, Ashuach, Tal, Inoue, Fumitaka, Khodaverdian, Alex, Deng, Chengyu, Yosef, Nir, Ahituv, Nadav |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938438/ https://www.ncbi.nlm.nih.gov/pubmed/35315433 http://dx.doi.org/10.1038/s41467-022-28659-0 |
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