Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis

Bombyx Papi acts as a scaffold for Siwi-piRISC biogenesis on the mitochondrial surface. Papi binds first to Siwi via the Tudor domain and subsequently to piRNA precursors loaded onto Siwi via the K-homology (KH) domains. This second action depends on phosphorylation of Papi. However, the underlying...

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Detalles Bibliográficos
Autores principales: Yamada, Hiromi, Nishida, Kazumichi M., Iwasaki, Yuka W., Isota, Yosuke, Negishi, Lumi, Siomi, Mikiko C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938449/
https://www.ncbi.nlm.nih.gov/pubmed/35314687
http://dx.doi.org/10.1038/s41467-022-29193-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938449/
https://www.ncbi.nlm.nih.gov/pubmed/35314687
http://dx.doi.org/10.1038/s41467-022-29193-9

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