A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylase SIRT6 regulates tumor initiation during intestinal cancer by controlling glucose metaboli...

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Detalles Bibliográficos
Autores principales: Sebastian, Carlos, Ferrer, Christina, Serra, Maria, Choi, Jee-Eun, Ducano, Nadia, Mira, Alessia, Shah, Manasvi S., Stopka, Sylwia A., Perciaccante, Andrew J., Isella, Claudio, Moya-Rull, Daniel, Vara-Messler, Marianela, Giordano, Silvia, Maldi, Elena, Desai, Niyati, Capen, Diane E., Medico, Enzo, Cetinbas, Murat, Sadreyev, Ruslan I., Brown, Dennis, Rivera, Miguel N., Sapino, Anna, Breault, David T., Agar, Nathalie Y. R., Mostoslavsky, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938512/
https://www.ncbi.nlm.nih.gov/pubmed/35314684
http://dx.doi.org/10.1038/s41467-022-29085-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938512/
https://www.ncbi.nlm.nih.gov/pubmed/35314684
http://dx.doi.org/10.1038/s41467-022-29085-y

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