COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm

ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von Willebrand factor (VWF), newly released from vascular endothelial cells. The ratio of ADAMTS13 activity to VWF antigen (ADAMTS13/VWF) and indicators of the alternative complement pathway (C3a and sC5b-9) are both re...

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Detalles Bibliográficos
Autores principales: Fujimura, Yoshihiro, Holland, Linda Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938647/
https://www.ncbi.nlm.nih.gov/pubmed/35316498
http://dx.doi.org/10.1007/s12185-022-03324-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938647/
https://www.ncbi.nlm.nih.gov/pubmed/35316498
http://dx.doi.org/10.1007/s12185-022-03324-w

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