Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care

IMPORTANCE: Aminoglycosides are commonly prescribed antibiotics used for the treatment of neonatal sepsis. The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity (AIO). Current genotyping approaches take several days, which is unfeasible in acute settings. OBJECT...

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Detalles Bibliográficos
Autores principales: McDermott, John H., Mahaveer, Ajit, James, Rachel A., Booth, Nicola, Turner, Mark, Harvey, Karen E., Miele, Gino, Beaman, Glenda M., Stoddard, Duncan C., Tricker, Karen, Corry, Rachel J., Garlick, Julia, Ainsworth, Shaun, Beevers, Thomas, Bruce, Iain A., Body, Richard, Ulph, Fiona, MacLeod, Rhona, Roberts, Peter L., Wilson, Paul M., Newman, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938898/
https://www.ncbi.nlm.nih.gov/pubmed/35311942
http://dx.doi.org/10.1001/jamapediatrics.2022.0187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938898/
https://www.ncbi.nlm.nih.gov/pubmed/35311942
http://dx.doi.org/10.1001/jamapediatrics.2022.0187

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