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Structure–Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents

[Image: see text] Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes, and aberrant sialic acid expression is associated with several pathologies, such as cancer. Strategies to interfere with the sialic acid biosynthesi...

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Detalles Bibliográficos
Autores principales: Moons, Sam J., Rossing, Emiel, Janssen, Mathilde A. C. H., Heise, Torben, Büll, Christian, Adema, Gosse J., Boltje, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938927/
https://www.ncbi.nlm.nih.gov/pubmed/35179348
http://dx.doi.org/10.1021/acschembio.1c00868