Evolutionary Stability Optimizer (ESO): A Novel Approach to Identify and Avoid Mutational Hotspots in DNA Sequences While Maintaining High Expression Levels

[Image: see text] Modern synthetic biology procedures rely on the ability to generate stable genetic constructs that keep their functionality over long periods of time. However, maintenance of these constructs requires energy from the cell and thus reduces the host’s fitness. Natural selection resul...

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Detalles Bibliográficos
Autores principales: Menuhin-Gruman, Itamar, Arbel, Matan, Amitay, Niv, Sionov, Karin, Naki, Doron, Katzir, Itai, Edgar, Omer, Bergman, Shaked, Tuller, Tamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938948/
https://www.ncbi.nlm.nih.gov/pubmed/34928133
http://dx.doi.org/10.1021/acssynbio.1c00426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938948/
https://www.ncbi.nlm.nih.gov/pubmed/34928133
http://dx.doi.org/10.1021/acssynbio.1c00426

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