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Copper-Catalyzed Azide–Alkyne Cycloaddition of Hydrazoic Acid Formed In Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles

[Image: see text] We report a copper-catalyzed cycloaddition of hydrogen azide (hydrazoic acid, HN(3)) with terminal alkynes to form 4-substituted-1H-1,2,3-triazoles in a sustainable manner. Hydrazoic acid was formed in situ from sodium azide under acidic conditions to react with terminal alkynes in...

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Detalles Bibliográficos
Autores principales: Jankovič, Dominik, Virant, Miha, Gazvoda, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938953/
https://www.ncbi.nlm.nih.gov/pubmed/35148087
http://dx.doi.org/10.1021/acs.joc.1c02775