Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms

Alternative splicing is an important cellular mechanism that fine tunes the gating properties of both voltage- and ligand-gated ion-channels. The cardiac voltage-gated sodium channel, Nav1.5, is subject to alternative splicing of the DI S3–S4 linker, which generates two types of channels with differ...

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Detalles Bibliográficos
Autores principales: Mancino, Adamo S., Glass, William G., Yan, Yuhao, Biggin, Philip C., Bowie, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939363/
https://www.ncbi.nlm.nih.gov/pubmed/35297947
http://dx.doi.org/10.1085/jgp.202112906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939363/
https://www.ncbi.nlm.nih.gov/pubmed/35297947
http://dx.doi.org/10.1085/jgp.202112906

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