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Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms
Alternative splicing is an important cellular mechanism that fine tunes the gating properties of both voltage- and ligand-gated ion-channels. The cardiac voltage-gated sodium channel, Nav1.5, is subject to alternative splicing of the DI S3–S4 linker, which generates two types of channels with differ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939363/ https://www.ncbi.nlm.nih.gov/pubmed/35297947 http://dx.doi.org/10.1085/jgp.202112906 |