MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly understood, due to the sparsity of measured affinities for t...

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Detalles Bibliográficos
Autores principales: McGeary, Sean E, Bisaria, Namita, Pham, Thy M, Wang, Peter Y, Bartel, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940178/
https://www.ncbi.nlm.nih.gov/pubmed/35191832
http://dx.doi.org/10.7554/eLife.69803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940178/
https://www.ncbi.nlm.nih.gov/pubmed/35191832
http://dx.doi.org/10.7554/eLife.69803

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