Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual’s...

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Detalles Bibliográficos
Autores principales: Russell, Magdalena L, Souquette, Aisha, Levine, David M, Schattgen, Stefan A, Allen, E Kaitlynn, Kuan, Guillermina, Simon, Noah, Balmaseda, Angel, Gordon, Aubree, Thomas, Paul G, Matsen, Frederick A, Bradley, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940181/
https://www.ncbi.nlm.nih.gov/pubmed/35315770
http://dx.doi.org/10.7554/eLife.73475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940181/
https://www.ncbi.nlm.nih.gov/pubmed/35315770
http://dx.doi.org/10.7554/eLife.73475

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