Functional Loss and Mortality in Randomized Clinical Trials for Amyotrophic Lateral Sclerosis: To Combine, or Not to Combine—That is the Estimand

Amyotrophic lateral sclerosis is a rapidly progressive disease leading to death in, on average, 3–5 years after first symptom onset. Consequently, there are frequently a non‐negligible number of patients who die during the course of a clinical trial. This introduces bias in end points such as daily...

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Detalles Bibliográficos
Autores principales: van Eijk, Ruben P.A., Roes, Kit C.B., de Greef‐van der Sandt, Inez, van den Berg, Leonard H., Lu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940672/
https://www.ncbi.nlm.nih.gov/pubmed/35076930
http://dx.doi.org/10.1002/cpt.2533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940672/
https://www.ncbi.nlm.nih.gov/pubmed/35076930
http://dx.doi.org/10.1002/cpt.2533

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