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Inferring pulmonary exposure based on clinical PK data: accuracy and precision of model-based deconvolution methods
Determining and understanding the target-site exposure in clinical studies remains challenging. This is especially true for oral drug inhalation for local treatment, where the target-site is identical to the site of drug absorption, i.e., the lungs. Modeling and simulation based on clinical pharmaco...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940815/ https://www.ncbi.nlm.nih.gov/pubmed/34585333 http://dx.doi.org/10.1007/s10928-021-09780-x |