Transcription factors modulate RNA polymerase conformational equilibrium

RNA polymerase (RNAP) frequently pauses during the transcription of DNA to RNA to regulate gene expression. Transcription factors NusA and NusG modulate pausing, have opposing roles, but can bind RNAP simultaneously. Here we report cryo-EM reconstructions of Escherichia coli RNAP bound to NusG, or N...

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Detalles Bibliográficos
Autores principales: Zhu, Chengjin, Guo, Xieyang, Dumas, Philippe, Takacs, Maria, Abdelkareem, Mo’men, Vanden Broeck, Arnaud, Saint-André, Charlotte, Papai, Gabor, Crucifix, Corinne, Ortiz, Julio, Weixlbaumer, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940904/
https://www.ncbi.nlm.nih.gov/pubmed/35318334
http://dx.doi.org/10.1038/s41467-022-29148-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940904/
https://www.ncbi.nlm.nih.gov/pubmed/35318334
http://dx.doi.org/10.1038/s41467-022-29148-0

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