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Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat
NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surprisingly, we found no effect on either cancellous or cortical bon...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940989/ https://www.ncbi.nlm.nih.gov/pubmed/35318397 http://dx.doi.org/10.1038/s41598-022-08914-6 |