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High-dose-androgen-induced autophagic cell death to suppress the Enzalutamide-resistant prostate cancer growth via altering the circRNA-BCL2/miRNA-198/AMBRA1 signaling

Androgen deprivation therapy (ADT) is a gold standard treatment for advanced PCa. However, most patients eventually develop the castration-resistant prostate cancer (CRPC) that progresses rapidly despite ongoing systemic androgen deprivation. While early studies indicated that high physiological dos...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Sun, Yin, Tang, Min, Wu, Denglong, Xiang, Zhendong, Huang, Chi-Ping, You, Bosen, Xie, Dongdong, Ye, Qinglin, Yu, Dexin, Chang, Chawnshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941094/
https://www.ncbi.nlm.nih.gov/pubmed/35318303
http://dx.doi.org/10.1038/s41420-022-00898-6