S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions

Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal...

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Detalles Bibliográficos
Autores principales: Jiang, Qiwei, Zhang, Xiaomei, Dai, Xiaoming, Han, Shiyao, Wu, Xueji, Wang, Lei, Wei, Wenyi, Zhang, Ning, Xie, Wei, Guo, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941131/
https://www.ncbi.nlm.nih.gov/pubmed/35318320
http://dx.doi.org/10.1038/s41467-022-28910-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941131/
https://www.ncbi.nlm.nih.gov/pubmed/35318320
http://dx.doi.org/10.1038/s41467-022-28910-8

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