Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type. The discovery of bacterial and human plasminogen activators and their use as thrombolytic drugs have revolutionized treatment of these patholog...

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Detalles Bibliográficos
Autores principales: Nikitin, Dmitri, Mican, Jan, Toul, Martin, Bednar, David, Peskova, Michaela, Kittova, Patricia, Thalerova, Sandra, Vitecek, Jan, Damborsky, Jiri, Mikulik, Robert, Fleishman, Sarel J., Prokop, Zbynek, Marek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941168/
https://www.ncbi.nlm.nih.gov/pubmed/35386102
http://dx.doi.org/10.1016/j.csbj.2022.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941168/
https://www.ncbi.nlm.nih.gov/pubmed/35386102
http://dx.doi.org/10.1016/j.csbj.2022.03.004

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