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Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type. The discovery of bacterial and human plasminogen activators and their use as thrombolytic drugs have revolutionized treatment of these patholog...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941168/ https://www.ncbi.nlm.nih.gov/pubmed/35386102 http://dx.doi.org/10.1016/j.csbj.2022.03.004 |