Cargando…

Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells

Elevated fasting blood glucose (FBG) is associated with increased risks of developing type 2 diabetes (T2D) and cardiovascular-associated mortality. G6PC2 is predominantly expressed in islets, encodes a glucose-6-phosphatase catalytic subunit that converts glucose-6-phosphate (G6P) to glucose, and h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rahim, Mohsin, Nakhe, Arya Y., Banerjee, Deveena R., Overway, Emily M., Bosma, Karin J., Rosch, Jonah C., Oeser, James K., Wang, Bo, Lippmann, Ethan S., Jacobson, David A., O'Brien, Richard M., Young, Jamey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941207/ https://www.ncbi.nlm.nih.gov/pubmed/35176280 http://dx.doi.org/10.1016/j.jbc.2022.101729

Ejemplares similares

Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1
por: Claxton, Derek P., et al.
Publicado: (2021)

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose
por: Overway, Emily M., et al.
Publicado: (2021)

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting
por: Bosma, Karin J., et al.
Publicado: (2020)

Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications
por: Mistry, Anoop, et al.
Publicado: (2017)

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
por: Oeser, James K., et al.
Publicado: (2011)

IP(3)Rs puff along: A SNAPpy dance with IP(3) and Ca(2+)
por: Nakhe, Arya Y., et al.
Publicado: (2023)

Protein Phosphatase 1 β Paralogs Encode the Zebrafish Myosin Phosphatase Catalytic Subunit
por: Jayashankar, Vaishali, et al.
Publicado: (2013)

The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer
por: Hang, Junjie, et al.
Publicado: (2021)

Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase
por: Vidal-Alabró, Anna, et al.
Publicado: (2011)

The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults
por: Nakhe, Arya Y., et al.
Publicado: (2023)

The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc)
por: Youn, Dou Yeon, et al.
Publicado: (2021)

Glucose-6-phosphatase deficiency
por: Froissart, Roseline, et al.
Publicado: (2011)

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets
por: Wall, Martha L., et al.
Publicado: (2015)

G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
por: Pound, Lynley D., et al.
Publicado: (2013)

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
por: Vietri, Michele, et al.
Publicado: (2006)

Hypomethylation of the promoter of the catalytic subunit of protein phosphatase 2A in response to hyperglycemia
por: Tros, Fabiola, et al.
Publicado: (2014)

Anchored phosphatases modulate glucose homeostasis
por: Hinke, Simon A, et al.
Publicado: (2012)

Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development
por: Beier, Anna, et al.
Publicado: (2016)

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism
por: Wang, Ya-nan, et al.
Publicado: (2021)

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
por: Hoermann, Bernhard, et al.
Publicado: (2020)

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis
por: Lei, Wen-Long, et al.
Publicado: (2021)

The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer
por: Hu, Lingyu, et al.
Publicado: (2021)

Myosin light chain phosphatase catalytic subunit dephosphorylates cardiac myosin via mechanisms dependent and independent of the MYPT regulatory subunits
por: Lee, Eunyoung, et al.
Publicado: (2022)

Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein
por: Gautier-Stein, Amandine, et al.
Publicado: (2012)

Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression
por: Boortz, Kayla A., et al.
Publicado: (2016)

Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
por: Luo, Xiaolin, et al.
Publicado: (2011)

A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production
por: Gautier-Stein, Amandine, et al.
Publicado: (2023)

mRNA Levels of Catalytic Subunits of Protein Phosphatases 1, 2A, and 2C in Hepatocarcinogenesis
por: Kitamura, Kazuki, et al.
Publicado: (1992)

Mutagenesis Study of the Cytochrome c Subunit Responsible for the Direct Electron Transfer-Type Catalytic Activity of FAD-Dependent Glucose Dehydrogenase
por: Yamashita, Yuki, et al.
Publicado: (2018)

X-ray structure of the direct electron transfer-type FAD glucose dehydrogenase catalytic subunit complexed with a hitchhiker protein
por: Yoshida, Hiromi, et al.
Publicado: (2019)

TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ
por: Wang, Xin, et al.
Publicado: (2019)

Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β
por: Müller, Margit S., et al.
Publicado: (2018)

On the Roles of Wheat Endosperm ADP-Glucose Pyrophosphorylase Subunits
por: Ferrero, Danisa M. L., et al.
Publicado: (2018)

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation
por: Toyo-oka, Kazuhito, et al.
Publicado: (2008)

Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis
por: Wang, YiLi, et al.
Publicado: (2023)

Rational Redesign of Glucose Oxidase for Improved Catalytic Function and Stability
por: Holland, J. Todd, et al.
Publicado: (2012)

Glucose-oxidase like catalytic mechanism of noble metal nanozymes
por: Chen, Jinxing, et al.
Publicado: (2021)

AuPt Bimetallic Nanozymes for Enhanced Glucose Catalytic Oxidase
por: Chen, Feixiang, et al.
Publicado: (2022)

Pt/CNT Micro-Nanorobots Driven by Glucose Catalytic Decomposition
por: Wang, Hao, et al.
Publicado: (2021)

The Catalytic Subunit of Protein Phosphatase 1 Gamma Regulates Thrombin-Induced Murine Platelet α(IIb)β(3) Function
por: Gushiken, Francisca C., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_4tmjcuqicn686eeu874g3fk5gu