Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins

During ricin intoxication in mammalian cells, ricin's enzymatic (RTA) and binding (RTB) subunits disassociate in the endoplasmic reticulum. RTA is then translocated into the cytoplasm where, by virtue of its ability to depurinate a conserved residue within the sarcin–ricin loop (SRL) of 28S rRN...

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Detalles Bibliográficos
Autores principales: Czajka, Timothy F., Vance, David J., Davis, Simon, Rudolph, Michael J., Mantis, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941211/
https://www.ncbi.nlm.nih.gov/pubmed/35182523
http://dx.doi.org/10.1016/j.jbc.2022.101742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941211/
https://www.ncbi.nlm.nih.gov/pubmed/35182523
http://dx.doi.org/10.1016/j.jbc.2022.101742

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