Cargando…
Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins
During ricin intoxication in mammalian cells, ricin's enzymatic (RTA) and binding (RTB) subunits disassociate in the endoplasmic reticulum. RTA is then translocated into the cytoplasm where, by virtue of its ability to depurinate a conserved residue within the sarcin–ricin loop (SRL) of 28S rRN...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941211/ https://www.ncbi.nlm.nih.gov/pubmed/35182523 http://dx.doi.org/10.1016/j.jbc.2022.101742 |