SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair

The activation of DNA‐dependent kinase (DNA‐PKcs) upon DNA damage contains a cascade of reactions, covering acetylation by TIP60, binding with Ku70/80, and autophosphorylation. However, how cells regulate TIP60‐mediated acetylation of DNA‐PKcs and the following DNA‐PKcs activation upon DNA damage re...

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Detalles Bibliográficos
Autores principales: Han, Yang, Huang, Xin, Cao, Xiaoyu, Li, Yuchen, Gao, Lei, Jia, Jin, Li, Gang, Guo, Hejiang, Liu, Xiaochang, Zhao, Hongling, Guan, Hua, Zhou, Pingkun, Gao, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941250/
https://www.ncbi.nlm.nih.gov/pubmed/35356800
http://dx.doi.org/10.1002/mco2.123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941250/
https://www.ncbi.nlm.nih.gov/pubmed/35356800
http://dx.doi.org/10.1002/mco2.123

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