Modelling the genetic aetiology of complex disease: human–mouse conservation of noncoding features and disease-associated loci

Understanding the genetic aetiology of loci associated with a disease is crucial for developing preventative measures and effective treatments. Mouse models are used extensively to understand human pathobiology and mechanistic functions of disease-associated loci. However, the utility of mouse model...

Descripción completa

Detalles Bibliográficos
Autores principales: Powell, George, Long, Helen, Zolkiewski, Louisa, Dumbell, Rebecca, Mallon, Ann-Marie, Lindgren, Cecilia M., Simon, Michelle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Genome Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941414/
https://www.ncbi.nlm.nih.gov/pubmed/35317627
http://dx.doi.org/10.1098/rsbl.2021.0630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941414/
https://www.ncbi.nlm.nih.gov/pubmed/35317627
http://dx.doi.org/10.1098/rsbl.2021.0630

Ejemplares similares