The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain

Tankyrases are ADP-ribosylating enzymes that regulate many physiological processes in the cell and are considered promising drug targets for cancer and fibrotic diseases. The catalytic ADP-ribosyltransferase domain of tankyrases contains a unique zinc-binding motif of unknown function. Recently, thi...

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Detalles Bibliográficos
Autores principales: Sowa, Sven T., Lehtiö, Lari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941426/
https://www.ncbi.nlm.nih.gov/pubmed/35317661
http://dx.doi.org/10.1098/rsob.210365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941426/
https://www.ncbi.nlm.nih.gov/pubmed/35317661
http://dx.doi.org/10.1098/rsob.210365

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