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The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain
Tankyrases are ADP-ribosylating enzymes that regulate many physiological processes in the cell and are considered promising drug targets for cancer and fibrotic diseases. The catalytic ADP-ribosyltransferase domain of tankyrases contains a unique zinc-binding motif of unknown function. Recently, thi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941426/ https://www.ncbi.nlm.nih.gov/pubmed/35317661 http://dx.doi.org/10.1098/rsob.210365 |