Cargando…

The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling

Antibiotic therapy, especially when administered long term, is associated with adverse hematologic effects such as cytopenia. Signals from the intestinal microbiota are critical to maintain normal hematopoiesis, and antibiotics can cause bone marrow suppression through depletion of the microbiota. W...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Hannah, Walker, Forrest C., Ali, Arushana, Han, Hyojeong, Tan, Lin, Veillon, Lucas, Lorenzi, Philip L., Baldridge, Megan T., King, Katherine Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Hematopoiesis and Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941453/ https://www.ncbi.nlm.nih.gov/pubmed/35143611 http://dx.doi.org/10.1182/bloodadvances.2021006816

Ejemplares similares

Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesis
por: Li, Yanan, et al.
Publicado: (2023)

An NFIX-mediated regulatory network governs the balance of hematopoietic stem and progenitor cells during hematopoiesis
por: Walker, Megan, et al.
Publicado: (2022)

De novo hematopoiesis from the fetal lung
por: Yeung, Anthony K., et al.
Publicado: (2023)

Association of clonal hematopoiesis with chronic obstructive pulmonary disease
por: Miller, Peter G., et al.
Publicado: (2022)

TET2-mutant clonal hematopoiesis and risk of gout
por: Agrawal, Mridul, et al.
Publicado: (2022)

ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice
por: Bloom, Mackenzie, et al.
Publicado: (2023)

Aging drives Tet2(+/−) clonal hematopoiesis via IL-1 signaling
por: Caiado, Francisco, et al.
Publicado: (2023)

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice
por: Avellino, Roberto, et al.
Publicado: (2022)

An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor
por: Khan, D M Isha Olive, et al.
Publicado: (2023)

Dissecting the role of SWI/SNF component ARID1B in steady-state hematopoiesis
por: Madan, Vikas, et al.
Publicado: (2023)

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis
por: Kurtova, Antonina V., et al.
Publicado: (2022)

Clonal hematopoiesis in patients with stem cell mobilization failure: a nested case-control study
por: Hazenberg, Carin L. E., et al.
Publicado: (2022)

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
por: Arede, Liliana, et al.
Publicado: (2022)

Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish
por: Mahony, Christopher B., et al.
Publicado: (2021)

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy
por: SanMiguel, Jennifer M., et al.
Publicado: (2022)

Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature
por: Sommarin, Mikael N. E., et al.
Publicado: (2023)

TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling
por: Peña, Oscar A., et al.
Publicado: (2021)

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis
por: Gerosa, Rahel C., et al.
Publicado: (2021)

GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program
por: Johnson, Kirby D., et al.
Publicado: (2022)

Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation
por: Zeng, Xiangjun, et al.
Publicado: (2023)

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs
por: Subramanian, Shruthi, et al.
Publicado: (2023)

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo
por: Demel, Uta Margareta, et al.
Publicado: (2022)

Machine learning–based scoring models to predict hematopoietic stem cell mobilization in allogeneic donors
por: Xiang, Jingyu, et al.
Publicado: (2022)

Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
por: Igarashi, Kyomi J., et al.
Publicado: (2023)

R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling
por: Chan, Kathy Yuen Yee, et al.
Publicado: (2021)

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
por: Sharma, Richa, et al.
Publicado: (2022)

Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification
por: Etra, Aaron, et al.
Publicado: (2022)

Phase 2 study of natalizumab plus standard corticosteroid treatment for high-risk acute graft-versus-host disease
por: Al Malki, Monzr M., et al.
Publicado: (2023)

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes
por: Walne, Amanda J., et al.
Publicado: (2008)

spib is required for primitive myeloid development in Xenopus
por: Costa, Ricardo M. B., et al.
Publicado: (2008)

A HaemAtlas: characterizing gene expression in differentiated human blood cells
por: Watkins, Nicholas A., et al.
Publicado: (2009)

STAT1 is essential for HSC function and maintains MHCII(hi) stem cells that resist myeloablation and neoplastic expansion
por: Li, Juan, et al.
Publicado: (2022)

Epigenetic plasticity of erythroid progenitors
por: Brand, Marjorie
Publicado: (2021)

Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood
por: Root, Sierra H., et al.
Publicado: (2021)

Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress
por: Landspersky, Theresa, et al.
Publicado: (2022)

Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
por: Mizuno, Kana, et al.
Publicado: (2022)

M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands
por: Hason, Martina, et al.
Publicado: (2022)

Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches
por: Yu, Zhuo, et al.
Publicado: (2022)

A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation
por: Wang, Fengjiao, et al.
Publicado: (2021)

A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation
por: Rowan, Courtney M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8prs5clo58t5gf8he3h9bb5v31